CI 75470 (Carmine)

CI 75470 (Carmine/Natural Red 4) is a broadly permitted natural insect-derived colorant in both EU and US regulatory frameworks, listed in EU Annex IV as a permitted colorant for all cosmetics. FDA permanently lists it exempt from certification for cosmetics and drugs, including eye area use—the only organic pink/red colorant with US eye-area authorization. Moderate concern rating reflects documented IgE-mediated sensitization potential and mandatory label declaration requirements. Safety is good for non-sensitized individuals; formulators must declare by INCI name 'Carmine' on labels. Animal-derived (insect) origin is relevant for vegan-free formulations. The EU classifies CI 75470 (Carmine) as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

CI 75470 (Carmine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

CI 75470 (Carmine) functions as: Colorant. Natural red pigment derived from the dried bodies of female cochineal insects (Dactylopius coccus Costa); also known as Carmine, Cochineal, Crimson Lake, Carmine Lake, Natural Red 4, and food colorant E120. The active chromophore is carminic acid precipitated with aluminium or calcium salts. Imparts bright red-pink coloration to cosmetic products including lipsticks, eyeshadows, and blushes. The only organic red/pink colorant approved for eye area use in the US. Purity criteria per Commission Directive 95/45/EC.. It is classified as a cosmetic ingredient in our database. CAS number: 1390-65-4.

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for CI 75470 (Carmine) is 500 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.