Is Carmine safe in cosmetics?
Carmine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Colorant
Carmine
Also known as: B Rose liquid, Carmine (Coccus cacti L.), Cochineal (Coccus cacti L.), Cochineal extract lake, EINECS 215-724-4 (+8 more)
INCI: CARMINE
Carmine (CAS 1390-65-4) is a cosmetic colorant functioning as colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 1390-65-4 →
Auto-generated CPSR Part A draft with source citations
Function
colorant
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in all cosmetics including eye area under 21 CFR 73.2087; batch certification exempt; FDA mandates prominent labeling declaration stating contains carmine as color additive.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Carmine.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| ADI | <=5 mg/kg | Human | oral | - | WHO JECFA ADI |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| GCC | halal_restricted | - | All cosmetics |
| BR | permitted_colorant | - | Column 1: All products |
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
colorant_formulator
{"ci_number": "75470", "ci_name": "Natural Red 4", "color_category": "red", "color_hex_code": "#DC143C", "natural_or_synthetic": "natural", "organic_or_inorganic": "organic", "lake_or_dye": "dye", "fda_approved_use": "lip/general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "transparent", "tinting_strength": "high", "lightfastness_rating": …
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, propylene glycol", "insoluble_in": "oils, ethanol, glycerin, silicones", "log_p": "-2.5", "appearance": "red powder/liquid", "source": "Colorcon"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Dye
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Carmine.
Regulatory Flags
color-additive
fda-exempt-certification
annex-iv-permitted
allergen-risk
ige-mediated-hypersensitivity
animal-derived
insect-derived
not-vegan
labeling-required
fda_food_additive
Known Synonyms
B Rose liquid
Carmine (Coccus cacti L.)
Cochineal (Coccus cacti L.)
Cochineal extract lake
EINECS 215-724-4
FEMA No. 2242
FEMA No. 2330
Carmine aluminum lake
Carmine red
CC 1000WS
CCRIS 1204
215-724-4
EC No.: 215-724-4
Chemical Function
Deodorizer
Dye
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Carmine (FDA)
ADI
5 mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is Carmine allowed in the EU?
Carmine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carmine do in cosmetics?
Carmine functions as: colorant. It is classified as a Colorant in our database. CAS number: 1390-65-4.
Is Carmine used outside cosmetics?
Carmine also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Carmine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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CI 75470 (Carmine)
Good
Chemical family
Colorant. Natural red pigment derived...
Carmine (CI 75470)
Good
Chemical family
Deodorizer; Dye; Flavouring and nutrient
Cochineal (CI 75470 / Carmine)
Good
Chemical family
Colorant, masking agent
Is Carmine in Your Products?
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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Carmine in your formulation.