Is CI 77400 (Copper Powder) safe in cosmetics?
CI 77400 (Copper Powder) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
CI 77400 (Copper Powder)
Also known as: Copper (Cu), Copper foil, M1, M3, M4 (+15 more)
INCI: CI 77400
CI 77400 (Copper Powder) (CAS 7440-50-8) is a cosmetic cosmetic ingredient functioning as Colorant. Finely powdered metallic copper or copper alloy (copper with zinc,. EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7440-50-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CI 77400 (Copper Powder) is classified GHS Danger (H302, H400, H410, H411, H317, H335, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant. Finely powdered metallic copper or copper alloy (copper with zinc, aluminum, or tin). Imparts warm bronze-gold metallic tones to cosmetic products. Used in eye shadows, eyepencils, nail polish, lip gloss, tinted balms, blushes, and illuminating products. Suspected endocrine disrupting properties have been noted; potential eye irritancy requires attention in formulation.
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
copper
InChIKey
RYGMFSIKBFXOCR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Listed as a color additive exempt from certification under 21 CFR 73.2647. Copper Powder may be safely used in coloring cosmetics generally, including cosmetics intended for use in the area of the eye, in amounts consistent with good manufacturing practice.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 77400 (Copper Powder).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarnEnviroAqua
Hazard Statements
Flammable solid Harmful if swallowed Very toxic to aquatic life with long lasting effects
Short-term Exposure Effects
Inhalation of fumes may cause metal fume fever. See Notes.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Ingestion may cause effects on the liver.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| MRL | =0.02 mg/kg-day | Human | oral | - | ATSDR MRLs |
| MRL | =0.02 mg/kg-day | Human | oral | - | ATSDR MRLs |
| RfD | =0.04 mg/kg-day | Human | oral | chronic | Copper Manufacturers |
| LOEL | =100 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LOEL | =200 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LOEL | =200 mg/kg-day | Rat | oral | short-term | ECOTOX |
| NOEL | =100 mg/kg-day | Rat | oral | short-term | ECOTOX |
| NOEL | =200 mg/kg-day | Rat | oral | short-term | ECOTOX |
| NOEL | =200 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LOEC | =200 mg/kg-day | Rat | oral | short-term | ECOTOX |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Environmental Hazard
Hazard Class and Category
Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 10; M = 1
Inserted via ATP: ATP22
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1726
(EU) 2024/858
Annex IV — Permitted Colorants
Product type: Brown
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_colorant | - | Column 3: Not near mucous membranes |
| ASEAN | permitted_colorant | - | Not mucous membranes; not around eyes |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "Bronze Powder", "Chemical_Name": "Copper-tin alloy", "CAS_Number": "Various", "Colorant_Type": "Metallic Pigment", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved", "Notes": "Metallic bronze effect"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Evidence for Carcinogenicity
Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity | CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: There are no human data, inadequate animal data from assays of copper compounds, and equivocal mutagenicity data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Inadequate.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0240
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The fumes and dust cause irritation of the upper respiratory tract. | Inhalation of copper fume results in the irritation of the upper respiratory tract. ... Contact with copper fumes will also cause irritation of the eyes, nose and throat. /Copper fumes/ | Copper or copper salts may induce allergic contact dermatitis in susceptible individuals. Signs & symptoms include itching, redness, swelling,
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
COPPER | 1982 | The level of copper in food meets the nutritional requirements (2-3 mg/day for adults; 0.5-0.7 mg/day for infants). Copper is not carcinogenic in either humans or animals, and copper salts are not embryotoxic in rodents. Highly-exposed populations do not appear to be adversely affected, nor does copper appear to be a cumulative toxic hazard for man, except for individuals with Wils
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Alloying element
Biocide
Conductive agent
Corrosion inhibitor
Degradant/impurity
Dye
Pigment
Plating agent
Solvent
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 77400 (Copper Powder).
Regulatory Flags
inorganic-colorant
metallic-pigment
eu-annex-iv
eu-unrestricted
fda-exempt-certification
eye-area-permitted
suspected-endocrine-disruptor
potential-eye-irritant
aquatic-ecotoxicity
cir-deferred
eu_cosing_listed
Known Synonyms
Copper (Cu)
Copper foil
M1
M3
M4
Caswell No. 227
CI Pigment metal 2
Copper bronze
Copper slag-airborne
Copper slag-milled
Copper-airborne
Copper-milled
EINECS 231-159-6
EPA Pesticide Chemical Code 022501
Gold bronze
OFHC Cu
Copper fulleride
Paragard T 380a
Tatum-T
UNII-789U1901C5
Chemical Function
Pigment
Dye
Solvent
Regulatory Lists
pharmaceutical
Personal care
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
1271
Frequently Asked Questions
Is CI 77400 (Copper Powder) allowed in the EU?
CI 77400 (Copper Powder) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 77400 (Copper Powder) do in cosmetics?
CI 77400 (Copper Powder) functions as: Colorant. Finely powdered metallic copper or copper alloy (copper with zinc, aluminum, or tin). Imparts warm bronze-gold metallic tones to cosmetic products. Used in eye shadows, eyepencils, nail polish, lip gloss, tinted balms, blushes, and illuminating products. Suspected endocrine disrupting properties have been noted; potential eye irritancy requires attention in formulation.. It is classified as a cosmetic ingredient in our database. CAS number: 7440-50-8.
Is CI 77400 (Copper Powder) classified as hazardous under GHS?
CI 77400 (Copper Powder) carries a GHS signal word of "DANGER". Hazard statements: Flammable solid Harmful if swallowed Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is CI 77400 (Copper Powder) used outside cosmetics?
CI 77400 (Copper Powder) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CI 77400 (Copper Powder) have different safety status in cosmetics vs industrial chemicals?
CI 77400 (Copper Powder) is classified GHS Danger (H302, H400, H410, H411, H317, H335, H370, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check CI 77400 (Copper Powder) compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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