Is CI 77510 (Ferric Ferrocyanide) safe in cosmetics?
CI 77510 (Ferric Ferrocyanide) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
CI 77510 (Ferric Ferrocyanide)
Also known as: Prussian blue, CI 77510 Blue, Iron ferrocyanide (Fe4[Fe(CN)6]3), EC No.: 237-875-5, EINECS 237-875-5 (+12 more)
INCI: CI 77510
CI 77510 (Ferric Ferrocyanide) (CAS 14038-43-8) is a cosmetic cosmetic ingredient functioning as Colorant. Inorganic complex iron pigment also known as Prussian Blue (Pigment. Reported NOAEL =25 mg/kg bw/day in rat (2207; male/female) (FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z); EU Regulation 1223/2009 status: permitted, max Listed in Annex IV of EU Cosmetics Regulation (EC) No. 1223/2009; permitted as a colorant in all cosmetics and personal care products; must be free from cyanide ions. Industrial safety data is also available in the chemical safety database. Same-CAS pub
View industrial chemical safety profile for CAS 14038-43-8 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant. Inorganic complex iron pigment also known as Prussian Blue (Pigment Blue 27). Chemical formula Fe4[Fe(CN)6]3. Produces a deep, vivid blue color in cosmetic formulations. Used in eye shadows, eyeliners, mascaras, hair coloring products, and nail polishes. The cyanide groups are tightly bound to the iron lattice and are not released under normal conditions of use. Approved for cosmetics as both Ferric Ferrocyanide and Ferric Ammonium Ferrocyanide variants. Must be free from cyanide ions per regulatory requirements.
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
tris(iron(2+));tetrakis(iron(3+));octadecacyanide
InChIKey
DCYOBGZUOMKFPA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
Listed in Annex IV of EU Cosmetics Regulation (EC) No. 1223/2009; permitted as a colorant in all cosmetics and personal care products; must be free from cyanide ions
US US Status
permitted
US Notes
Listed as a color additive exempt from certification under 21 CFR 73.2725 (Ferric Ferrocyanide) and 73.2726 (Ferric Ammonium Ferrocyanide). Permitted for coloring externally applied cosmetics, including products intended for use in the area of the eye. Not permitted in lip products (lipstick). FDA specifies a maximum of 10 ppm soluble cyanide.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 77510 (Ferric Ferrocyanide).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for CI 77510 (Ferric Ferrocyanide). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| BR | permitted_colorant | - | Column 2: All products except eye area |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "Ferric Ammonium Ferrocyanide", "Chemical_Name": "Iron blue", "CAS_Number": "25869-00-5", "Colorant_Type": "Inorganic Pigment", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 73.1200", "Notes": "Blue shade"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Dye
Expert Verdict
Expert safety assessment and concern-level summary for CI 77510 (Ferric Ferrocyanide).
Regulatory Flags
inorganic-colorant
iron-complex
prussian-blue
eu-annex-iv
eu-unrestricted
fda-exempt-certification
eye-area-permitted
not-for-lips-us
cyanide-bound
purity-requirements
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 77510 (Ferric Ferrocyanide) by CAS number or substance name.
Studies
5
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
25 mg/kg bw/day
ToxValDB_ECHA_IUCLID
FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z
Known Synonyms
Prussian blue
CI 77510 Blue
Iron ferrocyanide (Fe4[Fe(CN)6]3)
EC No.: 237-875-5
EINECS 237-875-5
Iron hexacyanoferrate
Tetrairon(3+) tris(hexacyanoferrate(4-))
Iron(3 ) hexacyanoferrate(4-) (4:3)
Insoluble Prussian Blue
UNII-TLE294X33A
Berliner Blau
Fe4[Fe(CN)6]3
Preussischblau
Turnbulls Blau
iron(3+) hexacyanoferrate(4-)
iron(III) hexacyanoferrate(II)
237-875-5
Chemical Function
Dye
Abrasive
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Personal care
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
prussian blue
ChEMBL ID
CHEMBL2096629
Frequently Asked Questions
Is CI 77510 (Ferric Ferrocyanide) allowed in the EU?
CI 77510 (Ferric Ferrocyanide) EU regulatory status: permitted. Maximum allowed concentration: Listed in Annex IV of EU Cosmetics Regulation (EC) No. 1223/2009; permitted as a colorant in all cosmetics and personal care products; must be free from cyanide ions. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 77510 (Ferric Ferrocyanide) do in cosmetics?
CI 77510 (Ferric Ferrocyanide) functions as: Colorant. Inorganic complex iron pigment also known as Prussian Blue (Pigment Blue 27). Chemical formula Fe4[Fe(CN)6]3. Produces a deep, vivid blue color in cosmetic formulations. Used in eye shadows, eyeliners, mascaras, hair coloring products, and nail polishes. The cyanide groups are tightly bound to the iron lattice and are not released under normal conditions of use. Approved for cosmetics as both Ferric Ferrocyanide and Ferric Ammonium Ferrocyanide variants. Must be free from cyanide ions per regulatory requirements.. It is classified as a cosmetic ingredient in our database. CAS number: 14038-43-8.
What is the NOAEL for CI 77510 (Ferric Ferrocyanide)?
The NOAEL (No Observed Adverse Effect Level) for CI 77510 (Ferric Ferrocyanide) is =25 mg/kg bw/day based on a repeated dose toxicity oral study via oral: feed route in rat (2207; male/female). A total of 5 study endpoints are available. Source: FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z.
Is CI 77510 (Ferric Ferrocyanide) used outside cosmetics?
CI 77510 (Ferric Ferrocyanide) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 77510 (Ferric Ferrocyanide) compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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