Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Cineole (1,8-Cineole / Eucalyptol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Skin penetration enhancer that may increase absorption of other ingredients; flammable; may cause allergic skin reaction at higher concentrations; contraindicated near face and nose of infants and young children
Regulatory Flags
Frequently Asked Questions
Is Cineole (1,8-Cineole / Eucalyptol) safe in cosmetics?
Skin penetration enhancer that may increase absorption of other ingredients; flammable; may cause allergic skin reaction at higher concentrations; contraindicated near face and nose of infants and young children The EU classifies Cineole (1,8-Cineole / Eucalyptol) as "prohibited". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Cineole (1,8-Cineole / Eucalyptol) allowed in the EU?
Cineole (1,8-Cineole / Eucalyptol) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cineole (1,8-Cineole / Eucalyptol) do in cosmetics?
Cineole (1,8-Cineole / Eucalyptol) functions as: Denaturant, fragrance, masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 470-82-6.
What is the Margin of Safety for Cineole (1,8-Cineole / Eucalyptol)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cineole (1,8-Cineole / Eucalyptol)?
The NOAEL (No Observed Adverse Effect Level) for Cineole (1,8-Cineole / Eucalyptol) is 500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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