Is Cineole (1,8-Cineole / Eucalyptol) safe in cosmetics?
Cineole (1,8-Cineole / Eucalyptol) has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Cineole (1,8-Cineole / Eucalyptol)
Also known as: Eucalyptol, EINECS 207-431-5, FEMA No. 2465, NCI-C56575, 2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane (+4 more)
INCI: CINEOLE
Cineole (1,8-Cineole / Eucalyptol) (CAS 470-82-6) is a cosmetic cosmetic ingredient functioning as Denaturant, fragrance, masking agent. NOAEL 33.3333 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 470-82-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cineole (1,8-Cineole / Eucalyptol) is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Denaturant, fragrance, masking agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
InChIKey
WEEGYLXZBRQIMU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted in cosmetics; CIR assessed as safe in present practices of use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cineole (1,8-Cineole / Eucalyptol).
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Cineole (1,8-Cineole / Eucalyptol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =1000 mg/kg bw | oral: gavage | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =1000 mg/kg bw | oral: gavage | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =64.15 mg/kg bw/day | oral | Mouse | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cineole (1,8-Cineole / Eucalyptol) across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
5 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =562.5 mg/kg-day | Mouse | oral | short-term | EFSA |
| LOAEL | =250 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| LOAEL | =100 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =64.15 mg/kg-day | Mouse | oral | short-term | ECHA IUCLID |
| LD50 | =2480 mg/kg | Rat | oral | - | ChemIDplus |
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 108 | 0 | 591 | 591 | non-sensitizer |
| HMT | - | 0 | 10368 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
1234
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,8-CINEOLE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
EUCALYPTOL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cineole (1,8-Cineole / Eucalyptol).
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cineole (1,8-Cineole / Eucalyptol) by CAS number or substance name.
Studies
5
Lowest NOAEL
64.15
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/day, mg/kg bw
ToxValDB_ECHA_IUCLID
COSMOS_DB
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
Eucalyptol
EINECS 207-431-5
FEMA No. 2465
NCI-C56575
2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane
1,8-Oxido-p-menthane
Soledum
Eukalyptol
UNII-RV6J6604TK
Chemical Function
Fragrance
Humectant
Flavouring and nutrient
Regulatory Lists
Europe
active_ingredient; Europe; Pesticides
active_ingredient; Australia
active_ingredient; animal_products; Europe; pharmaceutical; residue
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior - auto air freshener
air; Cleaning products and household care - air freshener; detected; emissions; Europe
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - liniment
Europe; Personal care - liniment
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EUCALYPTOL
ChEMBL ID
CHEMBL485259
Max Phase
3
Adverse Event Associations
5
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
EUCALYPTOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Cineole (1,8-Cineole / Eucalyptol) allowed in the EU?
Cineole (1,8-Cineole / Eucalyptol) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cineole (1,8-Cineole / Eucalyptol) do in cosmetics?
Cineole (1,8-Cineole / Eucalyptol) functions as: Denaturant, fragrance, masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 470-82-6.
What is the NOAEL for Cineole (1,8-Cineole / Eucalyptol)?
The NOAEL (No Observed Adverse Effect Level) for Cineole (1,8-Cineole / Eucalyptol) is 200 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Cineole (1,8-Cineole / Eucalyptol) used outside cosmetics?
Cineole (1,8-Cineole / Eucalyptol) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cineole (1,8-Cineole / Eucalyptol) have different safety status in cosmetics vs industrial chemicals?
Cineole (1,8-Cineole / Eucalyptol) is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H317).
Compliance Tools
Check Cineole (1,8-Cineole / Eucalyptol) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
CINEOLE
Good
Chemical family
Skin Protecting
Cineole (Eucalyptol)
Moderate
Chemical family
Denaturant; fragrance
Eucalyptol Cosmetic
Good
Chemical family
denaturant in SD Alcohol 38-B
Is Cineole (1,8-Cineole / Eucalyptol) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cineole (1,8-Cineole / Eucalyptol) in your formulation.