Cineole (Eucalyptol)
INCI: EUCALYPTOL (CINEOLE / 1,8-CINEOLE ARE COMMON SYNONYMS)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Cineole (Eucalyptol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Skin and mucous membrane irritation at high concentrations; may enhance percutaneous absorption of other ingredients (penetration enhancer effect); potential neurotoxicity in young children when ingested; the SCCS has evaluated it as a component of tea tree oil with noted skin sensitization potential. Bicyclic monoterpene ether (C₁₀H₁₈O). Constitutes 54-95% of Eucalyptus globulus leaf oil. Provides a cooling, camphoraceous aroma. Exhibits antibacterial and anti-inflammatory properties. Acts a...
Regulatory Flags
Frequently Asked Questions
Is Cineole (Eucalyptol) safe in cosmetics?
Skin and mucous membrane irritation at high concentrations; may enhance percutaneous absorption of other ingredients (penetration enhancer effect); potential neurotoxicity in young children when ingested; the SCCS has evaluated it as a component of tea tree oil with noted skin sensitization potential. Bicyclic monoterpene ether (C₁₀H₁₈O). Constitutes 54-95% of Eucalyptus globulus leaf oil. Provides a cooling, camphoraceous aroma. Exhibits antibacterial and anti-inflammatory properties. Acts a... The EU classifies Cineole (Eucalyptol) as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Cineole (Eucalyptol) allowed in the EU?
Cineole (Eucalyptol) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cineole (Eucalyptol) do in cosmetics?
Cineole (Eucalyptol) functions as: Denaturant; fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 470-82-6.
What is the Margin of Safety for Cineole (Eucalyptol)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cineole (Eucalyptol)?
The NOAEL (No Observed Adverse Effect Level) for Cineole (Eucalyptol) is 500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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