Cinnamonitrile

INCI: CINNAMONITRILE

CAS Number
4360-47-8 (isomer unspecified); 1885-38-7 (E-isomer, cinnamyl nitrile)
Function
Fragrance ingredient with spicy, cinnamon-like odor
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 0.077%
🇺🇸 US Status permitted
US Notes Permitted; no specific CIR monograph. RIFM safety assessment supports safe use at current declared levels

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Skin sensitizer with adequate margin of safety (WoE NESIL 1000 μg/cm²); positive in vitro clastogenicity but negative in vivo micronucleus with no overall genotoxic concern; photoallergenicity not yet evaluated; IFRA restricts use by product category.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Cinnamonitrile safe in cosmetics?

Skin sensitizer with adequate margin of safety (WoE NESIL 1000 μg/cm²); positive in vitro clastogenicity but negative in vivo micronucleus with no overall genotoxic concern; photoallergenicity not yet evaluated; IFRA restricts use by product category. The EU classifies Cinnamonitrile as "permitted". Safety rating: MODERATE.

Is Cinnamonitrile allowed in the EU?

Cinnamonitrile EU regulatory status: permitted. Maximum allowed concentration: 0.077%. This is based on EU Regulation 1223/2009 and its amendments.

What does Cinnamonitrile do in cosmetics?

Cinnamonitrile functions as: Fragrance ingredient with spicy, cinnamon-like odor. It is classified as a cosmetic ingredient in our database. CAS number: 4360-47-8 (isomer unspecified); 1885-38-7 (E-isomer, cinnamyl nitrile).

What is the Margin of Safety for Cinnamonitrile?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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