Good Cosmetic Ingredient NOAEL Data

Cinnamyl Acetate

INCI: CINNAMYL ACETATE

CAS Number
103-54-8
Function
Fragrance ingredient with balsamic, sweet, floral-cinnamon odor
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; FEMA GRAS. RIFM safety assessment supports use. Extensive RIFM data available.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Cinnamyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=600 mg/kg bw/day oral rat oral REACH

Expert Verdict

Eye irritant potential (H319) noted; not genotoxic and not a skin sensitizer at current use levels. Well-characterized with extensive RIFM data and serves as read-across analog for related cinnamyl esters.

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Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Cinnamyl Acetate safe in cosmetics?

Eye irritant potential (H319) noted; not genotoxic and not a skin sensitizer at current use levels. Well-characterized with extensive RIFM data and serves as read-across analog for related cinnamyl esters. The EU classifies Cinnamyl Acetate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Cinnamyl Acetate allowed in the EU?

Cinnamyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cinnamyl Acetate do in cosmetics?

Cinnamyl Acetate functions as: Fragrance ingredient with balsamic, sweet, floral-cinnamon odor. It is classified as a cosmetic ingredient in our database. CAS number: 103-54-8.

What is the Margin of Safety for Cinnamyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Cinnamyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Cinnamyl Acetate is >=600 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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