Cinnamyl Isobutyrate

INCI: CINNAMYL ISOBUTYRATE

CAS Number
103-59-3
Function
Fragrance ingredient with sweet, fruity, balsamic odor
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; FEMA GRAS for flavor use. RIFM member of the cinnamyl ester group. No specific CIR review.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited direct toxicological data relies on read-across from cinnamyl acetate; metabolizes to cinnamyl alcohol and cinnamaldehyde. A confirmatory sensitization study (DPRA or h-CLAT) may be requested for CPSR if read-across justification is insufficient.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Cinnamyl Isobutyrate safe in cosmetics?

Limited direct toxicological data relies on read-across from cinnamyl acetate; metabolizes to cinnamyl alcohol and cinnamaldehyde. A confirmatory sensitization study (DPRA or h-CLAT) may be requested for CPSR if read-across justification is insufficient. The EU classifies Cinnamyl Isobutyrate as "permitted". Safety rating: GOOD.

Is Cinnamyl Isobutyrate allowed in the EU?

Cinnamyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cinnamyl Isobutyrate do in cosmetics?

Cinnamyl Isobutyrate functions as: Fragrance ingredient with sweet, fruity, balsamic odor. It is classified as a cosmetic ingredient in our database. CAS number: 103-59-3.

What is the Margin of Safety for Cinnamyl Isobutyrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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