Is cis-3-Hexenyl Tiglate safe in cosmetics?
cis-3-Hexenyl Tiglate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
cis-3-Hexenyl Tiglate
Also known as: BRN 2961441, EINECS 267-554-5, cis-Hex-3-ene-1-yl trans-2-methyl-2-butenoate, cis-3-Hexenyl-2-methyl-trans-2-butenoate, (E,Z)-2-Methyl-2-butenoic acid 3-hexenyl ester (+1 more)
INCI: CIS-3-HEXENYL TIGLATE
cis-3-Hexenyl Tiglate (CAS 67883-79-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (green, fruity, slightly spicy). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 67883-79-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient (green, fruity, slightly spicy)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(Z)-hex-3-enyl] (E)-2-methylbut-2-enoate
InChIKey
JNWQKXUWZWKUAY-JQEGGOPCSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR monograph; RIFM safety assessment completed — deemed safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Tiglate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
cis-3-HEXENYL TIGLATE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/101 | FAS 42-JECFA 51/267 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Tiglate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
BRN 2961441
EINECS 267-554-5
cis-Hex-3-ene-1-yl trans-2-methyl-2-butenoate
cis-3-Hexenyl-2-methyl-trans-2-butenoate
(E,Z)-2-Methyl-2-butenoic acid 3-hexenyl ester
UNII-9S19N7N2QK
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183070
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
(Z)-3-HEXENYL(E)-2-METHYL-2-BUTENOATE
Food Category
flavoring
Frequently Asked Questions
Is cis-3-Hexenyl Tiglate allowed in the EU?
cis-3-Hexenyl Tiglate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Tiglate do in cosmetics?
cis-3-Hexenyl Tiglate functions as: Fragrance ingredient (green, fruity, slightly spicy). It is classified as a cosmetic ingredient in our database. CAS number: 67883-79-8.
Is cis-3-Hexenyl Tiglate used outside cosmetics?
cis-3-Hexenyl Tiglate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Tiglate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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