Is cis-Retinoic Acid safe in cosmetics?
cis-Retinoic Acid has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
cis-Retinoic Acid
INCI: CIS-RETINOIC ACID
cis-Retinoic Acid (CAS 4759-48-2 (13-cis-retinoic acid / isotretinoin)) is a cosmetic cosmetic ingredient functioning as Anti-sebum agent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 4759-48-2 (13-cis-retinoic acid / isotretinoin) →
Auto-generated CPSR Part A draft with source citations
CAS Number
4759-48-2 (13-cis-retinoic acid / isotretinoin)
View industrial chemical safety profile →
Function
Anti-sebum agent
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Prescription drug only (isotretinoin); not permitted in OTC cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-Retinoic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for cis-Retinoic Acid.
Frequently Asked Questions
Is cis-Retinoic Acid allowed in the EU?
cis-Retinoic Acid EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-Retinoic Acid do in cosmetics?
cis-Retinoic Acid functions as: Anti-sebum agent. It is classified as a cosmetic ingredient in our database. CAS number: 4759-48-2 (13-cis-retinoic acid / isotretinoin).
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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