Is Citral-Acid Isomerized safe in cosmetics?
Citral-Acid Isomerized has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Citral-Acid Isomerized
INCI: CITRAL
Citral-Acid Isomerized (CAS Typically reported under citral CAS 5392-40-5 (isomerized mixture)) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; flavoring. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
CAS Number
Typically reported under citral CAS 5392-40-5 (isomerized mixture)
View industrial chemical safety profile →
Function
Fragrance ingredient; flavoring
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
FEMA 2303; FDA GRAS; RIFM safety assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Citral-Acid Isomerized.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Citral-Acid Isomerized based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.8%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted
— max 0.6% in finished products
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Citral-Acid Isomerized, relevant to systemic exposure and MoS calculations.
Absorption %
18-30%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
152.2 Da
Log P
3.45
Systemic Absorption
yes
Topical Bioavailability
12-25%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS Opinion
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.3% | 7a (Deodorant – not spray) | 0.59% |
| 2 (Body spray) | 0.089% | 7b (Deodorant spray) | 0.59% |
| 3 (Body cream) | 0.3% | 8 (Face cream) | 0.099% |
| 4 (Fine fragrance) | 1.2% | 9 (Soap) | 1.4% |
| 5a (Body lotion) | 0.3% | 10a (Household – non-spray) | 1.4% |
| 5b (Face cream leave-on) | 0.29% | 10b (Household – spray) | No Restriction% |
| 5c (Hand cream) | 0.3% | 11a (Intimate – leave-on) | 0.099% |
| 5d (Baby cream) | 0.099% | 11b (Intimate – rinse) | 0.099% |
| 6 (Mouthwash) | 0.29% | 12 (Not for consumer exposure) | No Restriction% |
Editorial summary
Preliminary editorial summary for Citral-Acid Isomerized — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fragrance-component
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Citral-Acid Isomerized by CAS number or substance name.
Studies
38
Lowest NOAEL
6
Highest NOAEL
4275
Units vary across source rows: mg/kg bw/day, mg/kg bw
COSMOS DB
EFSA
ECHA
Frequently Asked Questions
Is Citral-Acid Isomerized allowed in the EU?
Citral-Acid Isomerized EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Citral-Acid Isomerized do in cosmetics?
Citral-Acid Isomerized functions as: Fragrance ingredient; flavoring. It is classified as a cosmetic ingredient in our database. CAS number: Typically reported under citral CAS 5392-40-5 (isomerized mixture).
Compliance Tools
Check Citral-Acid Isomerized compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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