Moderate Cosmetic Ingredient Sensitization Data Dermal Penetration

Citral-Acid Isomerized

INCI: CITRAL

CAS Number
Typically reported under citral CAS 5392-40-5 (isomerized mixture)
Function
Fragrance ingredient; flavoring
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes FEMA 2303; FDA GRAS; RIFM safety assessed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Citral-Acid Isomerized based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.8%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted — max 0.6% in finished products

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Citral-Acid Isomerized, relevant to systemic exposure and MoS calculations.

Absorption %
18-30%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
152.2 Da
Log P
3.45
Systemic Absorption
yes
Topical Bioavailability
12-25%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

EU allergen requiring label declaration; acid isomerization shifts neral:geranial ratio which may affect sensitization profile; must comply with IFRA category-specific limits

⚠️
Concern Level: High

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Citral-Acid Isomerized safe in cosmetics?

EU allergen requiring label declaration; acid isomerization shifts neral:geranial ratio which may affect sensitization profile; must comply with IFRA category-specific limits The EU classifies Citral-Acid Isomerized as "restricted". Safety rating: MODERATE.

Is Citral-Acid Isomerized allowed in the EU?

Citral-Acid Isomerized EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citral-Acid Isomerized do in cosmetics?

Citral-Acid Isomerized functions as: Fragrance ingredient; flavoring. It is classified as a cosmetic ingredient in our database. CAS number: Typically reported under citral CAS 5392-40-5 (isomerized mixture).

What is the Margin of Safety for Citral-Acid Isomerized?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Citral-Acid Isomerized compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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