Is Citral-Acid Isomerized safe in cosmetics?
Citral-Acid Isomerized has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Citral-Acid Isomerized
INCI: CITRAL
Citral-Acid Isomerized (CAS Typically reported under citral CAS 5392-40-5 (isomerized mixture)) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; flavoring. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Typically reported under citral CAS 5392-40-5 (isomerized mixture)
View industrial chemical safety profile →
Function
Fragrance ingredient; flavoring
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
FEMA 2303; FDA GRAS; RIFM safety assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Citral-Acid Isomerized.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Citral-Acid Isomerized based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.8%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted
— max 0.6% in finished products
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Citral-Acid Isomerized, relevant to systemic exposure and MoS calculations.
Absorption %
18-30%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
152.2 Da
Log P
3.45
Systemic Absorption
yes
Topical Bioavailability
12-25%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS/1459/11, IFRA
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.3% | 7a (Deodorant – not spray) | 0.59% |
| 2 (Body spray) | 0.089% | 7b (Deodorant spray) | 0.59% |
| 3 (Body cream) | 0.3% | 8 (Face cream) | 0.099% |
| 4 (Fine fragrance) | 1.2% | 9 (Soap) | 1.4% |
| 5a (Body lotion) | 0.3% | 10a (Household – non-spray) | 1.4% |
| 5b (Face cream leave-on) | 0.29% | 10b (Household – spray) | No Restriction% |
| 5c (Hand cream) | 0.3% | 11a (Intimate – leave-on) | 0.099% |
| 5d (Baby cream) | 0.099% | 11b (Intimate – rinse) | 0.099% |
| 6 (Mouthwash) | 0.29% | 12 (Not for consumer exposure) | No Restriction% |
Additional Ingredient Properties
8 property records from structured ingredient metadata.
acne
{"cas_number": "5392-40-5", "anti_acne_mechanism": "antibacterial", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "100-500", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "Max 1%", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": …
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "fragrance-mix-II", "patch_test_frequency_pct": "1.8", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "ifra_max_level_pct": "0.6", "source": "ESSCA/IVDK"}
concentration
{"min_concentration_pct": "0.01", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.2", "product_type": "Toner", "function_at_concentration": "Fragrance component", "source": "EU Cosmetics Regulation (labeling required)"}
dermal_absorption
{"molecular_weight_da": "152.2", "log_p_value": "3.45", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis/dermis", "absorption_pct": "18-30", "systemic_absorption": "yes", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "12-25", "safety_margin_factor": "high", "source": "SCCS/…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "14-28", "bioaccumulative": "no", "aquatic_toxicity_level": "moderate", "coral_reef_safe": "yes", "marine_toxicity": "moderate aquatic toxicity", "freshwater_toxicity": "moderate fish toxicity", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environ…
fragrance
{"cas_number": "5392-40-5", "ingredient_class": "natural_isolate", "chemical_class": "aldehyde", "odor_family": "citrus", "odor_description": "Strong lemon, citrus fresh", "odor_strength": "very_strong", "odor_tenacity_hours": "3.0", "top_note": "yes", "heart_note": "yes", "base_note": "no", "blending_factor_1_10": "9.0", "threshold_of_detection_ppb": "0.5", "molecular_weight_Da": "152.23", "boili…
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "caution", "safe_for_toddler_1_3y": "caution", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "1.0", "adult_max_concentration_pct": "unlimited", "pediatric_dermal_absorption_factor": "higher", "immature_skin_barrier_risk": "moderate", "oral_ingestion_risk": "low", "eye_irritation_risk": …
regulatory
{"eu_status": "restricted", "us_status": "allowed", "eu_max_concentration": "0.001", "restricted_in": "rinse-off: >0.01%, leave-on: >0.001%", "regulation_reference": "Annex III/205"}
Expert Verdict
Expert safety assessment and concern-level summary for Citral-Acid Isomerized.
Regulatory Flags
potential-allergen
fragrance-component
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Citral-Acid Isomerized by CAS number or substance name.
Studies
38
Lowest NOAEL
6
Highest NOAEL
4275
Units vary across source rows: mg/kg bw/day, mg/kg bw
COSMOS_DB
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Frequently Asked Questions
Is Citral-Acid Isomerized allowed in the EU?
Citral-Acid Isomerized EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Citral-Acid Isomerized do in cosmetics?
Citral-Acid Isomerized functions as: Fragrance ingredient; flavoring. It is classified as a cosmetic ingredient in our database. CAS number: Typically reported under citral CAS 5392-40-5 (isomerized mixture).
Compliance Tools
Check Citral-Acid Isomerized compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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