Citrullus Colocynthis Fruit Extract

INCI: CITRULLUS COLOCYNTHIS FRUIT EXTRACT

CAS Number
72986-41-5 / 84696-04-8
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not reviewed by CIR. No specific FDA monograph. Manufacturer responsibility for safety substantiation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Colocynth is a known purgative and toxic plant orally; cucurbitacins are cytotoxic. Limited dermal safety data for cosmetic use. Requires robust toxicological dossier in CPSR. Not a mainstream cosmetic botanical โ€” expect assessor scrutiny.

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Citrullus Colocynthis Fruit Extract safe in cosmetics?

Colocynth is a known purgative and toxic plant orally; cucurbitacins are cytotoxic. Limited dermal safety data for cosmetic use. Requires robust toxicological dossier in CPSR. Not a mainstream cosmetic botanical โ€” expect assessor scrutiny. The EU classifies Citrullus Colocynthis Fruit Extract as "permitted". Safety rating: MODERATE.

Is Citrullus Colocynthis Fruit Extract allowed in the EU?

Citrullus Colocynthis Fruit Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrullus Colocynthis Fruit Extract do in cosmetics?

Citrullus Colocynthis Fruit Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 72986-41-5 / 84696-04-8.

What is the Margin of Safety for Citrullus Colocynthis Fruit Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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