Civetone

INCI: CIVETONE

CAS Number
542-46-1
Function
Fragrance (macrocyclic musk)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA permitted for use in cosmetics as fragrance with no restrictions. Listed in EU Regulation 872/2012 Annex 1 as authorized flavouring.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mild skin irritant in rabbit models but non-irritant in human occlusive patch test; cytotoxic without metabolic activation but not genotoxic. Originally derived from civet cat glands, now predominantly synthetic. No allergen labelling required under EU Reg 2023/1545.

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Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component fda_food_additive

Frequently Asked Questions

Is Civetone safe in cosmetics?

Mild skin irritant in rabbit models but non-irritant in human occlusive patch test; cytotoxic without metabolic activation but not genotoxic. Originally derived from civet cat glands, now predominantly synthetic. No allergen labelling required under EU Reg 2023/1545. The EU classifies Civetone as "permitted". Safety rating: GOOD.

Is Civetone allowed in the EU?

Civetone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Civetone do in cosmetics?

Civetone functions as: Fragrance (macrocyclic musk). It is classified as a cosmetic ingredient in our database. CAS number: 542-46-1.

What is the Margin of Safety for Civetone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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