Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
RED FLAG: This is a pharmaceutical active, not a cosmetic ingredient in practice. Systemic exposure concern; contact sensitization documented; if included in a cosmetic CPSR, the Safety Assessor must justify cosmetic vs. pharmaceutical classification. Not suitable for leave-on cosmetics without extensive justification
Regulatory Flags
Frequently Asked Questions
Is Crotamiton safe in cosmetics?
RED FLAG: This is a pharmaceutical active, not a cosmetic ingredient in practice. Systemic exposure concern; contact sensitization documented; if included in a cosmetic CPSR, the Safety Assessor must justify cosmetic vs. pharmaceutical classification. Not suitable for leave-on cosmetics without extensive justification The EU classifies Crotamiton as "prohibited". Safety rating: POOR.
Is Crotamiton allowed in the EU?
Crotamiton EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Crotamiton do in cosmetics?
Crotamiton functions as: Anti-pruritic agent, antimicrobial (primarily pharmaceutical — used as scabicide in OTC drugs). It is classified as a cosmetic ingredient in our database. CAS number: 483-63-6.
What is the Margin of Safety for Crotamiton?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Crotamiton compliance across multiple jurisdictions:
Related Ingredients
Is Crotamiton in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Crotamiton in your formulation.