Regulatory Status
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Safety Data
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Expert Verdict
Limited long-term topical safety data in public domain; naturally occurring bioactive lipid; requires careful concentration management as it activates cell signaling pathways (LPAR1-Gi/o, PI3K, ERK). Demonstrated ability to induce hyaluronic acid synthesis in human skin fibroblasts via CREB transcription factor activation through the LPAR1 receptor and downstream PI3K/ERK signaling pathway; structurally related to lysophosphatidic acid (LPA) but with a cyclic phosphate group conferring distin...
Regulatory Flags
Frequently Asked Questions
Is Cyclic Lysophosphatidic Acid safe in cosmetics?
Limited long-term topical safety data in public domain; naturally occurring bioactive lipid; requires careful concentration management as it activates cell signaling pathways (LPAR1-Gi/o, PI3K, ERK). Demonstrated ability to induce hyaluronic acid synthesis in human skin fibroblasts via CREB transcription factor activation through the LPAR1 receptor and downstream PI3K/ERK signaling pathway; structurally related to lysophosphatidic acid (LPA) but with a cyclic phosphate group conferring distin... The EU classifies Cyclic Lysophosphatidic Acid as "permitted". Safety rating: MODERATE.
Is Cyclic Lysophosphatidic Acid allowed in the EU?
Cyclic Lysophosphatidic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclic Lysophosphatidic Acid do in cosmetics?
Cyclic Lysophosphatidic Acid functions as: Skin Conditioning; Anti-aging active. It is classified as a cosmetic ingredient in our database. CAS number: attending multiple isomers; the 1-oleoyl form (sodium salt) is CAS 208387-56-2.
What is the Margin of Safety for Cyclic Lysophosphatidic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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