Moderate Cosmetic Ingredient Dermal Penetration

Cyclopentasiloxane

INCI: CYCLOPENTASILOXANE

CAS Number
541-02-6
Function
solvent, emollient, volatile carrier, conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. โ‰ฅ0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restriction; no US cyclomethicone ban as of 2026; CIR assessed safe at use concentrations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Cyclopentasiloxane, relevant to systemic exposure and MoS calculations.

Absorption %
0.1-0.5%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
370.8 Da
Log P
5.2
Systemic Absorption
minimal
Topical Bioavailability
0.05-0.2%
Safety Margin Factor
minimal

Source: CIR

Expert Verdict

EU Reg 2024/1328 extended the D5 restriction from rinse-off only to all consumer and professional products at โ‰ฅ0.1% w/w, enforced June 6, 2026. ECHA SVHC since 2018 for vPvB and endocrine disruption properties. SCCS concluded safe for human health at use levels but environmental vPvB classification drove regulatory action. Functional alternatives include caprylyl methicone, hemisqualane, and isoamyl laurate.

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Concern Level: Moderate

Regulatory Flags

svhc vpvb endocrine-disruptor eu-restricted-2026 reach-reg-2024-1328 bioaccumulative environmental-hazard volatile-silicone cyclic-siloxane pops-candidate reformulate-required ifra_fragrance

Frequently Asked Questions

Is Cyclopentasiloxane safe in cosmetics?

EU Reg 2024/1328 extended the D5 restriction from rinse-off only to all consumer and professional products at โ‰ฅ0.1% w/w, enforced June 6, 2026. ECHA SVHC since 2018 for vPvB and endocrine disruption properties. SCCS concluded safe for human health at use levels but environmental vPvB classification drove regulatory action. Functional alternatives include caprylyl methicone, hemisqualane, and isoamyl laurate. The EU classifies Cyclopentasiloxane as "restricted". Safety rating: MODERATE.

Is Cyclopentasiloxane allowed in the EU?

Cyclopentasiloxane EU regulatory status: restricted. Maximum allowed concentration: โ‰ฅ0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclopentasiloxane do in cosmetics?

Cyclopentasiloxane functions as: solvent, emollient, volatile carrier, conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 541-02-6.

What is the Margin of Safety for Cyclopentasiloxane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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