Is Cyclohexyl Acetate safe in cosmetics?
Cyclohexyl Acetate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Cyclohexyl Acetate
Also known as: Acetic acid, cyclohexyl ester, 4-06-00-00036, Adronal acetate, BRN 1906543, Cyclohexane acetate (+9 more)
INCI: CYCLOHEXYL ACETATE
Cyclohexyl Acetate (CAS 622-45-7) is a cosmetic cosmetic ingredient functioning as Fragrance / perfuming agent. EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 622-45-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / perfuming agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
cyclohexyl acetate
InChIKey
YYLLIJHXUHJATK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - also GRAS (Generally Recognized as Safe) for food flavoring by FEMA, indicating a well-established safety profile.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclohexyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
FlamFlame
Hazard Statements
Flammable liquid and vapour Causes mild skin irritation Causes eye irritation
Short-term Exposure Effects
The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Ingestion of large amounts could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
Exposure mainly occurs via inhalation.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2592 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [76] Epstein WL (1977): Report to RIFM, 16 May, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
| HMT | - | 0 | 2592 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0426
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
EXPOSURE TO 516 PPM...CAUSED SOME IRRITATION OF PHARYNX, LARYNX & CONJUNCTIVA & AS. | Inhalation exposure of two men to 3 mg/l cyclohexyl acetate for 45 min produced eye and throat irritation.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
1093
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXANE ACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOHEXYL ACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cyclohexyl Acetate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Acetic acid, cyclohexyl ester
4-06-00-00036
Adronal acetate
BRN 1906543
Cyclohexane acetate
Cyclohexanol, acetate
Cyclohexanyl acetate
EINECS 210-736-6
FEMA No. 2349
Hexalin acetate
NSC 8772
Cyclohexanolazetat
Cyclohexylester kyseliny octove
UNII-UL0RS4H1UE
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cyclohexyl Acetate allowed in the EU?
Cyclohexyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclohexyl Acetate do in cosmetics?
Cyclohexyl Acetate functions as: Fragrance / perfuming agent. It is classified as a cosmetic ingredient in our database. CAS number: 622-45-7.
Is Cyclohexyl Acetate classified as hazardous under GHS?
Cyclohexyl Acetate carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Causes mild skin irritation Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Cyclohexyl Acetate used outside cosmetics?
Cyclohexyl Acetate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cyclohexyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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