Moderate Cosmetic Ingredient GHS Classified

Cyclohexyl Acetate

INCI: CYCLOHEXYL ACETATE

CAS Number
622-45-7
Function
Fragrance / perfuming agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - also GRAS (Generally Recognized as Safe) for food flavoring by FEMA, indicating a well-established safety profile.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
flam;flame
Hazard Statements
Flammable liquid and vapour Causes mild skin irritation Causes eye irritation
Short-term Exposure Effects
The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Ingestion of large amounts could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
Exposure mainly occurs via inhalation.

Expert Verdict

Hydrolyzed in vivo to cyclohexanol (CAS 108-93-0) and acetic acid (CAS 64-19-7). Low acute toxicity; mild skin and eye irritant at high concentrations.. Fruity, pear-like odor; volatile ester widely used in fragrance compounding; serves as a solvent-like carrier note in fruity accords.

⚠️
Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Cyclohexyl Acetate safe in cosmetics?

Hydrolyzed in vivo to cyclohexanol (CAS 108-93-0) and acetic acid (CAS 64-19-7). Low acute toxicity; mild skin and eye irritant at high concentrations.. Fruity, pear-like odor; volatile ester widely used in fragrance compounding; serves as a solvent-like carrier note in fruity accords. The EU classifies Cyclohexyl Acetate as "permitted". Safety rating: MODERATE.

Is Cyclohexyl Acetate allowed in the EU?

Cyclohexyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclohexyl Acetate do in cosmetics?

Cyclohexyl Acetate functions as: Fragrance / perfuming agent. It is classified as a cosmetic ingredient in our database. CAS number: 622-45-7.

What is the Margin of Safety for Cyclohexyl Acetate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Cyclohexyl Acetate classified as hazardous under GHS?

Cyclohexyl Acetate carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Causes mild skin irritation Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Cyclohexyl Acetate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

3-(O-Ethylphenyl)-2,2-Dimethylpropionaldehyde
Good
Isopropyl-p-Cresol
Moderate
Nonenol
Good
Pinus Mugo Pumilio Twig Leaf Extract
Moderate
2-Methyl-3-Oxopropoxy-Pyran-4-One
Moderate
Browse all 30,000+ ingredients →
📱

Is Cyclohexyl Acetate in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cyclohexyl Acetate in your formulation.

Ingredient Decoder MoS Calculator