Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Deoxyribonuclease. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1184.1 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1012.8 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Respiratory sensitization potential noted; bovine-sourced variants carry BSE/TSE prion risk requiring supplier certification; enzyme activity must be controlled to avoid over-exfoliation
Regulatory Flags
Frequently Asked Questions
Is Deoxyribonuclease safe in cosmetics?
Respiratory sensitization potential noted; bovine-sourced variants carry BSE/TSE prion risk requiring supplier certification; enzyme activity must be controlled to avoid over-exfoliation The EU classifies Deoxyribonuclease as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Deoxyribonuclease allowed in the EU?
Deoxyribonuclease EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Deoxyribonuclease do in cosmetics?
Deoxyribonuclease functions as: Skin conditioning enzyme; cleaves DNA in dead cells to aid exfoliation. It is classified as a cosmetic ingredient in our database. CAS number: 9003-98-9.
What is the Margin of Safety for Deoxyribonuclease?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Deoxyribonuclease?
The NOAEL (No Observed Adverse Effect Level) for Deoxyribonuclease is >=1184.1 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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