Is Dequalinium Chloride safe in cosmetics?
Dequalinium Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dequalinium Chloride
Also known as: Quinaldinium, 1,1′-decamethylenebis[4-amino-, dichloride, Quinolinium, 1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride, 1,1′-Decamethylenebis[4-aminoquinaldinium chloride], Quinolinium, 1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2), 1,10-Decamethylene-bis(4-aminoquinaldinium chloride) (+15 more)
INCI: DEQUALINIUM CHLORIDE
Dequalinium Chloride (CAS 522-51-0) is a cosmetic cosmetic ingredient functioning as Antimicrobial / preservative (quaternary ammonium compound). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 522-51-0 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial / preservative (quaternary ammonium compound)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-[10-(4-amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine dichloride
InChIKey
LTNZEXKYNRNOGT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not prohibited under 21 CFR; FDA recognizes as pharmaceutical active (UNII: XYS8INN1I6)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dequalinium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Deodorizer
Pharmaceutical
Expert Verdict
Expert safety assessment and concern-level summary for Dequalinium Chloride.
Regulatory Flags
preservative
Known Synonyms
Quinaldinium, 1,1′-decamethylenebis[4-amino-, dichloride
Quinolinium, 1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride
1,1′-Decamethylenebis[4-aminoquinaldinium chloride]
Quinolinium, 1,1′-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2)
1,10-Decamethylene-bis(4-aminoquinaldinium chloride)
Decamine
Decaminum
Dekadin
Dekamin
Dequadin
Dequafungan
Dequalin chloride
Dequavagyn
Dequavet
EINECS 208-330-9
Eriosept
Erosept
Grocreme
Labosept
NSC 166454
Chemical Function
Biocide
Deodorizer
Pharmaceutical
Regulatory Lists
pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DEQUALINIUM CHLORIDE
ChEMBL ID
CHEMBL121663
Max Phase
4
Frequently Asked Questions
Is Dequalinium Chloride allowed in the EU?
Dequalinium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dequalinium Chloride do in cosmetics?
Dequalinium Chloride functions as: Antimicrobial / preservative (quaternary ammonium compound). It is classified as a cosmetic ingredient in our database. CAS number: 522-51-0.
Is Dequalinium Chloride used outside cosmetics?
Dequalinium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dequalinium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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