Moderate Cosmetic Ingredient NOAEL Data GHS Classified SCCS/CIR Reviewed

DICHLOROMETHANE

CAS Number

75-09-2

Function

Perfuming, Solvent

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status Restricted

EU Max Conc. II/1389

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for DICHLOROMETHANE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	55 mg/kg bw/day	oral	rat	Carcinogenicity	COSMOS_DB
NOAEL	236 mg/kg bw/day	oral	mouse	Chronic	COSMOS_DB
NOAEL	236 mg/kg bw/day	oral	mouse	Carcinogenicity	COSMOS_DB
NOAEL	500 mg/kg bw/day	oral	rat	Carcinogenicity	COSMOS_DB
NOAEL	100 mg/kg bw/day	oral	mouse	Carcinogenicity	COSMOS_DB
NOAEL	166 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	1911 mg/kg bw/day	oral	mouse	Subchronic	COSMOS_DB
NOAEL	238 mg/kg bw/day	oral	mouse	Carcinogenicity	COSMOS_DB
NOAEL	5 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
LOAEL	50 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

skull;toxic; cancer;health haz

Hazard Statements

Harmful if swallowed Fatal if inhaled Causes skin and eye irritation May cause drowsiness or dizziness Causes damage to central nervous system, blood, liver, the heart and lungs May be harmful if swallowed and enters airways Causes damage to the central nervous system through prolonged or repeated exposure if inhaled May cause cancer

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system, blood, liver, heart and lungs. Exposure could cause carbon monoxide poisoning. This may result in impaired functions. Exposure at high concentrations could cause lowering of consciousness and death. The effects may be delayed.

Long-term Exposure Effects

The substance may have effects on the central nervous system. This substance is probably carcinogenic to humans.

Routes of Exposure

The substance can be absorbed into the body by inhalation, by ingestion and through the skin.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir Number 6, 1988

Verdict: unknown

Expert Verdict

DICHLOROMETHANE is listed in the EU CosIng database with functions: Perfuming, Solvent It is restricted under EU Cosmetics Regulation. Restriction: II/1389.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment endocrine_disruptor prop65 eu_banned_cosmetics fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is DICHLOROMETHANE safe in cosmetics?

DICHLOROMETHANE is listed in the EU CosIng database with functions: Perfuming, Solvent It is restricted under EU Cosmetics Regulation. Restriction: II/1389. The EU classifies DICHLOROMETHANE as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is DICHLOROMETHANE allowed in the EU?

DICHLOROMETHANE EU regulatory status: Restricted. Maximum allowed concentration: II/1389. This is based on EU Regulation 1223/2009 and its amendments.

What does DICHLOROMETHANE do in cosmetics?

DICHLOROMETHANE functions as: Perfuming, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 75-09-2.

What is the NOAEL for DICHLOROMETHANE?

The NOAEL (No Observed Adverse Effect Level) for DICHLOROMETHANE is 55 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is DICHLOROMETHANE classified as hazardous under GHS?

DICHLOROMETHANE carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed Fatal if inhaled Causes skin and eye irritation May cause drowsiness or dizziness Causes damage to central nervous system, blood, liver, the heart and lungs May be harmful if swallowed and enters airways Causes damage to the central nervous system through prolonged or repeated exposure if inhaled May cause cancer. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

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