Dibromopropamidine Diisethionate

INCI: DIBROMOPROPAMIDINE DIISETHIONATE

CAS Number
496-00-4
Function
Preservative (antimicrobial, diamidine class)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 0.1%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not prohibited under 21 CFR; also used in OTC ophthalmic preparations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strict concentration cap at 0.1%; structurally related to hexamidine diisethionate and dibromohexamidine; ensure formulation pH supports stability; isolated reports of allergic contact dermatitis in pharmaceutical use

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Concern Level: Moderate

Regulatory Flags

preservative

Frequently Asked Questions

Is Dibromopropamidine Diisethionate safe in cosmetics?

Strict concentration cap at 0.1%; structurally related to hexamidine diisethionate and dibromohexamidine; ensure formulation pH supports stability; isolated reports of allergic contact dermatitis in pharmaceutical use The EU classifies Dibromopropamidine Diisethionate as "permitted". Safety rating: GOOD.

Is Dibromopropamidine Diisethionate allowed in the EU?

Dibromopropamidine Diisethionate EU regulatory status: permitted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.

What does Dibromopropamidine Diisethionate do in cosmetics?

Dibromopropamidine Diisethionate functions as: Preservative (antimicrobial, diamidine class). It is classified as a cosmetic ingredient in our database. CAS number: 496-00-4.

What is the Margin of Safety for Dibromopropamidine Diisethionate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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