Diethyl Aspartate

INCI: DIETHYL ASPARTATE

CAS Number
43101-48-0 (DL-form) / 16845-02-6 (L-form free base)
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Amino acid diethyl ester expected to hydrolyze to L-aspartic acid and ethanol. Very limited cosmetic-use safety data. Related acylated form diethyl palmitoyl aspartate is better characterized. No CIR monograph.

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Concern Level: Moderate

Frequently Asked Questions

Is Diethyl Aspartate safe in cosmetics?

Amino acid diethyl ester expected to hydrolyze to L-aspartic acid and ethanol. Very limited cosmetic-use safety data. Related acylated form diethyl palmitoyl aspartate is better characterized. No CIR monograph. The EU classifies Diethyl Aspartate as "permitted". Safety rating: MODERATE.

Is Diethyl Aspartate allowed in the EU?

Diethyl Aspartate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethyl Aspartate do in cosmetics?

Diethyl Aspartate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 43101-48-0 (DL-form) / 16845-02-6 (L-form free base).

What is the Margin of Safety for Diethyl Aspartate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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