Diethyl Ketoglutarate

INCI: DIETHYL KETOGLUTARATE

CAS Number
13192-04-6
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Diester of alpha-ketoglutaric acid, a Krebs cycle intermediate, expected to hydrolyze to alpha-ketoglutarate and ethanol. Very limited published cosmetic toxicological data; no CIR or SCCS opinion available.

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Concern Level: Moderate

Frequently Asked Questions

Is Diethyl Ketoglutarate safe in cosmetics?

Diester of alpha-ketoglutaric acid, a Krebs cycle intermediate, expected to hydrolyze to alpha-ketoglutarate and ethanol. Very limited published cosmetic toxicological data; no CIR or SCCS opinion available. The EU classifies Diethyl Ketoglutarate as "permitted". Safety rating: MODERATE.

Is Diethyl Ketoglutarate allowed in the EU?

Diethyl Ketoglutarate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethyl Ketoglutarate do in cosmetics?

Diethyl Ketoglutarate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 13192-04-6.

What is the Margin of Safety for Diethyl Ketoglutarate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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