Moderate Cosmetic Ingredient NOAEL Data GHS Classified

DIETHYLHEXYL PHTHALATE

CAS Number
117-81-7
Function
Fragrance, Perfuming, Plasticiser, Solvent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. II/677
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for DIETHYLHEXYL PHTHALATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3 mg/kg bw/day oral - - SCCS_Perplexity

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Long-term Exposure Effects
The substance may have effects on the testes. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

DIETHYLHEXYL PHTHALATE is listed in the EU CosIng database with functions: Fragrance, Perfuming, Plasticiser, Solvent It is restricted under EU Cosmetics Regulation. Restriction: II/677.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment prop65 eu_banned_cosmetics ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is DIETHYLHEXYL PHTHALATE safe in cosmetics?

DIETHYLHEXYL PHTHALATE is listed in the EU CosIng database with functions: Fragrance, Perfuming, Plasticiser, Solvent It is restricted under EU Cosmetics Regulation. Restriction: II/677. The EU classifies DIETHYLHEXYL PHTHALATE as "Restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is DIETHYLHEXYL PHTHALATE allowed in the EU?

DIETHYLHEXYL PHTHALATE EU regulatory status: Restricted. Maximum allowed concentration: II/677. This is based on EU Regulation 1223/2009 and its amendments.

What does DIETHYLHEXYL PHTHALATE do in cosmetics?

DIETHYLHEXYL PHTHALATE functions as: Fragrance, Perfuming, Plasticiser, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 117-81-7.

What is the NOAEL for DIETHYLHEXYL PHTHALATE?

The NOAEL (No Observed Adverse Effect Level) for DIETHYLHEXYL PHTHALATE is 3 mg/kg bw/day based on a toxicological study via oral route in rat. Source: SCCS_Perplexity.

Compliance Tools

Check DIETHYLHEXYL PHTHALATE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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