Poor Cosmetic Ingredient NOAEL Data GHS Classified

Diethylhexyl Phthalate (DEHP)

INCI: DIETHYLHEXYL PHTHALATE

CAS Number
117-81-7
Function
Plasticizer
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Restricted in cosmetics; phthalates are subject to consumer product safety regulations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Diethylhexyl Phthalate (DEHP). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3 mg/kg bw/day oral - - SCCS_Perplexity

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Long-term Exposure Effects
The substance may have effects on the testes. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

Diethylhexyl Phthalate (DEHP) is prohibited in cosmetics in the EU due to reproductive and developmental toxicity concerns, and restricted in the US.

⚠️
Concern Level: High

Regulatory Flags

EU Restricted CMR prop65 eu_banned_cosmetics ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Diethylhexyl Phthalate (DEHP) safe in cosmetics?

Diethylhexyl Phthalate (DEHP) is prohibited in cosmetics in the EU due to reproductive and developmental toxicity concerns, and restricted in the US. The EU classifies Diethylhexyl Phthalate (DEHP) as "prohibited". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Diethylhexyl Phthalate (DEHP) allowed in the EU?

Diethylhexyl Phthalate (DEHP) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Diethylhexyl Phthalate (DEHP) do in cosmetics?

Diethylhexyl Phthalate (DEHP) functions as: Plasticizer. It is classified as a Cosmetic Ingredient in our database. CAS number: 117-81-7.

What is the Margin of Safety for Diethylhexyl Phthalate (DEHP)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diethylhexyl Phthalate (DEHP)?

The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Phthalate (DEHP) is 3 mg/kg bw/day based on a toxicological study via oral route in rat. Source: SCCS_Perplexity.

Compliance Tools

Check Diethylhexyl Phthalate (DEHP) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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