Is Diethylhexyl Succinate safe in cosmetics?
Diethylhexyl Succinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Emollient
Diethylhexyl Succinate
Also known as: Nitric acid, 2-ethylhexyl ester, EINECS 248-363-6, Ethylhexyl nitrate
INCI: DIETHYLHEXYL SUCCINATE
Diethylhexyl Succinate (CAS 27247-96-7) is a cosmetic emollient functioning as Emollient, Skin Conditioning, Solvent. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 27247-96-7 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, Skin Conditioning, Solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-ethylhexyl nitrate
InChIKey
NKRVGWFEFKCZAP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylhexyl Succinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethylhexyl Succinate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for Diethylhexyl Succinate.
Known Synonyms
Nitric acid, 2-ethylhexyl ester
EINECS 248-363-6
Ethylhexyl nitrate
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL401411
Frequently Asked Questions
Is Diethylhexyl Succinate allowed in the EU?
Diethylhexyl Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Succinate do in cosmetics?
Diethylhexyl Succinate functions as: Emollient, Skin Conditioning, Solvent. It is classified as a Emollient in our database. CAS number: 27247-96-7.
Is Diethylhexyl Succinate used outside cosmetics?
Diethylhexyl Succinate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethylhexyl Succinate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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