Also known as: 2,2'-Diethylhexylamine, 2,2'-Diethyldihexylamine, Di(2-ethylhexyl)amine, N,N-Bis(2-ethylhexyl)amine, N,N-Di(2-ethylhexyl)amine (+6 more)
INCI: DIETHYLHEXYLAMINE
Diethylhexylamine (Di-2-ethylhexylamine) (CAS 106-20-7) is a cosmetic cosmetic ingredient functioning as Listed in CosIng as a cosmetic ingredient; industrially used as a chemical. Reported NOAEL =30 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Diethylhexylamine (Di-2-ethylhexylamine) is classified GHS Danger (H302, H312, H311, H314, H318, H330, H331, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylhexylamine (Di-2-ethylhexylamine).
Calculate MoS for your specific formulation with the MoS Calculator.
2 study endpoints found for Diethylhexylamine (Di-2-ethylhexylamine). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg bw/day | oral | Rat | short-term | ECHA |
| NOAEL | =75 mg/kg bw/day | oral | Rat | short-term | ECHA |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Preliminary editorial summary for Diethylhexylamine (Di-2-ethylhexylamine) — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Diethylhexylamine (Di-2-ethylhexylamine) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Diethylhexylamine (Di-2-ethylhexylamine) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Diethylhexylamine (Di-2-ethylhexylamine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Diethylhexylamine (Di-2-ethylhexylamine) functions as: Listed in CosIng as a cosmetic ingredient; industrially used as a chemical intermediate and laboratory reagent. It is classified as a cosmetic ingredient in our database. CAS number: 106-20-7.
The NOAEL (No Observed Adverse Effect Level) for Diethylhexylamine (Di-2-ethylhexylamine) is =30 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Diethylhexylamine (Di-2-ethylhexylamine) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Diethylhexylamine (Di-2-ethylhexylamine) is classified GHS Danger (H302, H312, H311, H314, H318, H330, H331, H410) in the chemicals database but is allowed in EU cosmetics.
Check Diethylhexylamine (Di-2-ethylhexylamine) compliance across multiple jurisdictions:
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