Dihydro Pentamethylindanone (DPMI / Cashmeran) (CAS 33704-61-9) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient — synthetic musk/amber/woody note. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
US NotesPermitted — no specific CFR restriction; RIFM safety assessment available
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydro Pentamethylindanone (DPMI / Cashmeran).
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Toxicological Studies
1 study endpoint found for Dihydro Pentamethylindanone (DPMI / Cashmeran). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=10 mg/kg bw/day
oral
Rat
subchronic
ToxValDB_ECHA_IUCLID
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
DeodorizerFragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Dihydro Pentamethylindanone (DPMI / Cashmeran).
Is Dihydro Pentamethylindanone (DPMI / Cashmeran) safe in cosmetics?
Dihydro Pentamethylindanone (DPMI / Cashmeran) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Is Dihydro Pentamethylindanone (DPMI / Cashmeran) allowed in the EU?
Dihydro Pentamethylindanone (DPMI / Cashmeran) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydro Pentamethylindanone (DPMI / Cashmeran) do in cosmetics?
Dihydro Pentamethylindanone (DPMI / Cashmeran) functions as: Fragrance ingredient — synthetic musk/amber/woody note. It is classified as a cosmetic ingredient in our database. CAS number: 33704-61-9.
What is the NOAEL for Dihydro Pentamethylindanone (DPMI / Cashmeran)?
The NOAEL (No Observed Adverse Effect Level) for Dihydro Pentamethylindanone (DPMI / Cashmeran) is =10 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Dihydro Pentamethylindanone (DPMI / Cashmeran) used outside cosmetics?
Dihydro Pentamethylindanone (DPMI / Cashmeran) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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