Is Cashmeran safe in cosmetics?
Cashmeran has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Cashmeran
Also known as: 4H-Inden-4-one, 1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-, 1,2,3,5,6,7-Hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one, 6,7-Dihydro-1,1,2,3,3-pentamethyl-4-(5H)indanone, 6,7-Dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone, EINECS 251-649-3 (+3 more)
INCI: DIHYDRO PENTAMETHYLINDANONE
Cashmeran (CAS 33704-61-9) is a cosmetic fragrance functioning as Fragrance (synthetic woody-musky-amber material). Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 33704-61-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (synthetic woody-musky-amber material)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1,1,2,3,3-pentamethyl-2,5,6,7-tetrahydroinden-4-one
InChIKey
MIZGSAALSYARKU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
IFRA 51st Amendment (2023) explicitly names cashmeran as a preferred alternative to nitro musks; full compliance deadline Oct 2025
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cashmeran.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Cashmeran. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Cashmeran.
Regulatory Flags
ifra-preferred
clean-beauty-approved
musk-alternative
low-sensitization
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cashmeran by CAS number or substance name.
Studies
1
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
10 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
4H-Inden-4-one, 1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-
1,2,3,5,6,7-Hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one
6,7-Dihydro-1,1,2,3,3-pentamethyl-4-(5H)indanone
6,7-Dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone
EINECS 251-649-3
UNII-BZR4438MY4
Dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone
(+-)-Cashmeran
Chemical Function
Fragrance
Deodorizer
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183584
Frequently Asked Questions
Is Cashmeran allowed in the EU?
Cashmeran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cashmeran do in cosmetics?
Cashmeran functions as: Fragrance (synthetic woody-musky-amber material). It is classified as a Fragrance in our database. CAS number: 33704-61-9.
What is the NOAEL for Cashmeran?
The NOAEL (No Observed Adverse Effect Level) for Cashmeran is =10 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Cashmeran used outside cosmetics?
Cashmeran also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cashmeran compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Dihydromyrcenol
Excellent
Same category
Fragrance; aroma chemical; fresh/clea...
Hedione
Excellent
Same category
Perfuming, Fragrance Diffuser, Volume...
Iso E Super
Excellent
Same category
Fragrance; aroma chemical; woody/ambe...
Alpha-Isomethyl Ionone
Good
Same category
Fragrance ingredient
Anise Alcohol
Good
Same category
Fragrance ingredient
Anisic Acid
Good
Same category
Fragrance, Antimicrobial Preservation...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
DIHYDRO PENTAMETHYLINDANONE
Good
Chemical family
Fragrance, Perfuming
Dihydro Pentamethylindanone (DPMI / Cashmeran)
Moderate
Chemical family
Fragrance ingredient — synthetic musk...
OCTAHYDRO-PENTAMETHYL-INDENE
Good
Chemical family
Perfuming
Is Cashmeran in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cashmeran in your formulation.