Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dihydrocoumarin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 110 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 580 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2250 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Dihydrocoumarin based on clinical patch test studies and IFRA standards.
Source: EU 2023/1545; SCCS
Expert Verdict
Structurally similar to coumarin (Annex III allergen); Cramer Class III material with exposure levels below TTC (0.47 mg/day). Monitor for future regulatory reclassification.
Regulatory Flags
Frequently Asked Questions
Is Dihydrocoumarin safe in cosmetics?
Structurally similar to coumarin (Annex III allergen); Cramer Class III material with exposure levels below TTC (0.47 mg/day). Monitor for future regulatory reclassification. The EU classifies Dihydrocoumarin as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Dihydrocoumarin allowed in the EU?
Dihydrocoumarin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydrocoumarin do in cosmetics?
Dihydrocoumarin functions as: Fragrance ingredient with sweet, coumarin-like odor. It is classified as a cosmetic ingredient in our database. CAS number: 119-84-6.
What is the Margin of Safety for Dihydrocoumarin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihydrocoumarin?
The NOAEL (No Observed Adverse Effect Level) for Dihydrocoumarin is 110 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Dihydrocoumarin compliance across multiple jurisdictions:
Related Ingredients
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