Poor Cosmetic Ingredient NOAEL Data

4-Amino-2-Nitrophenol ⚠️

INCI: 4-AMINO-2-NITROPHENOL

CAS Number
119-34-6
Function
Hair Dyeing
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Not banned by FDA — still technically permitted under coal tar hair dye exemption, but CIR flagged concerns about potential carcinogenicity and mutagenicity.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for 4-Amino-2-Nitrophenol ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 250 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day dermal code:3484 dermal REACH
NOAEL 250 mg/kg bw/day oral mouse oral REACH

Expert Verdict

Potential carcinogenicity and mutagenicity identified by CIR. Banned in the EU. If formulating for any EU, UK, or ASEAN market — do not use. Even for US-market products, this is a significant liability risk.

⚠️
Concern Level: High

Regulatory Flags

prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4-Amino-2-Nitrophenol ⚠️ safe in cosmetics?

Potential carcinogenicity and mutagenicity identified by CIR. Banned in the EU. If formulating for any EU, UK, or ASEAN market — do not use. Even for US-market products, this is a significant liability risk. The EU classifies 4-Amino-2-Nitrophenol ⚠️ as "prohibited". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.

Is 4-Amino-2-Nitrophenol ⚠️ allowed in the EU?

4-Amino-2-Nitrophenol ⚠️ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Amino-2-Nitrophenol ⚠️ do in cosmetics?

4-Amino-2-Nitrophenol ⚠️ functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 119-34-6.

What is the Margin of Safety for 4-Amino-2-Nitrophenol ⚠️?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 4-Amino-2-Nitrophenol ⚠️?

The NOAEL (No Observed Adverse Effect Level) for 4-Amino-2-Nitrophenol ⚠️ is 250 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Compliance Tools

Check 4-Amino-2-Nitrophenol ⚠️ compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
Compare limits across jurisdictions

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