Is Diisopropanolamine safe in cosmetics?
Diisopropanolamine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Diisopropanolamine
Also known as: 2-Propanol, 1,1'-iminobis-, 3-04-00-00761, BRN 0605363, Dipropyl-2,2'-dihydroxy-amine, EINECS 203-820-9 (+1 more)
INCI: DIISOPROPANOLAMINE
Diisopropanolamine (CAS 110-97-4) is a cosmetic cosmetic ingredient functioning as pH adjuster / buffering agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-97-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diisopropanolamine is classified GHS Danger (H318, H319, H314) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster / buffering agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-(2-hydroxypropylamino)propan-2-ol
InChIKey
LVTYICIALWPMFW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR safe as used (1987, reaffirmed 2006); must not be used with N-nitrosating agents
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisopropanolamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the aerosol may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Eye Irrit. 2
Hazard Statements
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0493
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritates eyes, skin, nose
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Cleaning agent
Emulsifier
Stabilizing agent
pH regulating agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diisopropanolamine.
Known Synonyms
2-Propanol, 1,1'-iminobis-
3-04-00-00761
BRN 0605363
Dipropyl-2,2'-dihydroxy-amine
EINECS 203-820-9
UNII-0W44HYL8T5
Chemical Function
pH regulating agent
Stabilizing agent
Regulatory Lists
Europe; plastic_additive
inert_ingredient; non_food_use; Pesticides
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIISOPROPANOLAMINE
ChEMBL ID
CHEMBL2106303
Max Phase
-1
Frequently Asked Questions
Is Diisopropanolamine allowed in the EU?
Diisopropanolamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisopropanolamine do in cosmetics?
Diisopropanolamine functions as: pH adjuster / buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 110-97-4.
Is Diisopropanolamine used outside cosmetics?
Diisopropanolamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diisopropanolamine have different safety status in cosmetics vs industrial chemicals?
Diisopropanolamine is classified GHS Danger (H318, H319, H314) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Diisopropanolamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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