Poor Cosmetic Ingredient GHS Classified Sensitization Data

Dimethylaminopropylamine (DMAPA)

INCI: DIMETHYLAMINOPROPYLAMINE

CAS Number
109-55-7
Function
Buffering agent / intermediate (primarily encountered as an impurity in CAPB and amidoamine surfactants)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted with CIR caveats — CIR QRA indicates no sensitisation concern at ≤ 0.01% DMAPA in raw CAPB

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Sensitization Profile

Contact sensitization data for Dimethylaminopropylamine (DMAPA) based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
surfactant
EU Allergen Listed
no
Patch Test Positive Rate
2.0%
Cross-reactivity Group
amidoamine-group
Reaction Type
contact-dermatitis

Source: NACDG; IVDK; ESSCA

Expert Verdict

Known cause of allergic contact dermatitis from CAPB products; proposed CLP reclassification Skin Sens 1A; QRA-based formulation required; industry advised to minimise concentrations

⚠️
Concern Level: High

Frequently Asked Questions

Is Dimethylaminopropylamine (DMAPA) safe in cosmetics?

Known cause of allergic contact dermatitis from CAPB products; proposed CLP reclassification Skin Sens 1A; QRA-based formulation required; industry advised to minimise concentrations The EU classifies Dimethylaminopropylamine (DMAPA) as "prohibited". Safety rating: POOR.

Is Dimethylaminopropylamine (DMAPA) allowed in the EU?

Dimethylaminopropylamine (DMAPA) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethylaminopropylamine (DMAPA) do in cosmetics?

Dimethylaminopropylamine (DMAPA) functions as: Buffering agent / intermediate (primarily encountered as an impurity in CAPB and amidoamine surfactants). It is classified as a cosmetic ingredient in our database. CAS number: 109-55-7.

What is the Margin of Safety for Dimethylaminopropylamine (DMAPA)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Dimethylaminopropylamine (DMAPA) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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