Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Diosmin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=620 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=250 mg/kg bw/day | oral | code:3541 | oral | REACH |
Expert Verdict
Natural flavonoid glycoside from citrus plants with potent antioxidant and anti-inflammatory properties; used in soothing, sun care, and sensitive skin formulations; strong safety record in both pharmaceutical and cosmetic applications
Regulatory Flags
Frequently Asked Questions
Is Diosmin safe in cosmetics?
Natural flavonoid glycoside from citrus plants with potent antioxidant and anti-inflammatory properties; used in soothing, sun care, and sensitive skin formulations; strong safety record in both pharmaceutical and cosmetic applications The EU classifies Diosmin as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Diosmin allowed in the EU?
Diosmin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diosmin do in cosmetics?
Diosmin functions as: Antioxidant, Skin conditioning, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 520-27-4.
What is the Margin of Safety for Diosmin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diosmin?
The NOAEL (No Observed Adverse Effect Level) for Diosmin is >=200 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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