Is Diosmin safe in cosmetics?
Diosmin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Diosmin
Also known as: EINECS 208-289-7, Diosmine, Diosminum, Barosmin, Diosmetin-7-O-rutinoside (+15 more)
INCI: DIOSMIN
Diosmin (CAS 520-27-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin conditioning, Soothing. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 520-27-4 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Skin conditioning, Soothing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
InChIKey
GZSOSUNBTXMUFQ-YFAPSIMESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Sold as dietary supplement in the US; used in cosmetics without specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diosmin.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diosmin across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Diosmin.
Regulatory Flags
flavonoid
antioxidant
soothing
citrus-derived
Known Synonyms
EINECS 208-289-7
Diosmine
Diosminum
Barosmin
Diosmetin-7-O-rutinoside
3',5,7-Trihydroxy-4'-methoxyflavone-7-(6-O-(-deoxy-alpha-L-mannopyraonsyl)-beta-D-glucopyranoside
5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glycopyranosyl)oxy)-4-chromenon
Diosmil
Diovenor
Flebosten
Venosmine
Ven-Detrex
UNII-7QM776WJ5N
3',5-Dihydroxy-4'-methoxy-4-oxo-4H-chromen-7-ylrutosid
Buchu Resin
3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside
3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside
Diosmetin 7-O-rutinoside
diosmetin 7-neohesperidoside
neodiosmin
Chemical Function
Antioxidant
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIOSMIN
ChEMBL ID
CHEMBL231884
Max Phase
4
Adverse Event Associations
1854
Frequently Asked Questions
Is Diosmin allowed in the EU?
Diosmin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diosmin do in cosmetics?
Diosmin functions as: Antioxidant, Skin conditioning, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 520-27-4.
Is Diosmin used outside cosmetics?
Diosmin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diosmin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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