Is DITHIOTHREITOL safe in cosmetics?
DITHIOTHREITOL has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
DITHIOTHREITOL
Also known as: DTT (threitol derivative), rel-(2R,3R)-1,4-Dimercapto-2,3-butanedio, DTT, 3-01-00-02360, BRN 1719757 (+10 more)
DITHIOTHREITOL (CAS 3483-12-3) is a cosmetic cosmetic ingredient functioning as Hair Waving Or Straightening, Reducing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 3483-12-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
DITHIOTHREITOL is classified GHS Danger (H302, H315, H318, H319, H335, H412, H312) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Waving Or Straightening, Reducing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R,3R)-1,4-bis(sulfanyl)butane-2,3-diol
InChIKey
VHJLVAABSRFDPM-IMJSIDKUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair waving or straightening
Reducing agent
Expert Verdict
Expert safety assessment and concern-level summary for DITHIOTHREITOL.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
DTT (threitol derivative)
rel-(2R,3R)-1,4-Dimercapto-2,3-butanedio
DTT
3-01-00-02360
BRN 1719757
2,3-Butanediol, 1,4-dimercapto-, DL-threo-
Cleland reagent
(R*,R*)-(+/-)-1,4-Dimercapto-2,3-butanediol
D-1,4-Dithiothreitol
Dithiotreitol
EINECS 222-468-7
EINECS 248-531-9
D-threo-1,4-Dimercapto-2,3-butanediol
DL-threo-1,4-Dimercapto-2,3-butanediol
UNII-T8ID5YZU6Y
Chemical Function
Reducing agent
Hair waving or straightening
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is DITHIOTHREITOL allowed in the EU?
DITHIOTHREITOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DITHIOTHREITOL do in cosmetics?
DITHIOTHREITOL functions as: Hair Waving Or Straightening, Reducing. It is classified as a cosmetic ingredient in our database. CAS number: 3483-12-3.
Is DITHIOTHREITOL used outside cosmetics?
DITHIOTHREITOL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DITHIOTHREITOL have different safety status in cosmetics vs industrial chemicals?
DITHIOTHREITOL is classified GHS Danger (H302, H315, H318, H319, H335, H412, H312) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check DITHIOTHREITOL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Good
Similar safety
Antioxidant
Dithiothreitol (DTT)
Poor
Chemical family
Reducing agent primarily used as a la...
DL-1-Phenylpentan-2-ol
Moderate
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Perfuming (fragrance ingredient).
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