Good Active Ingredient NOAEL Data GHS Classified

DMAE (Dimethylaminoethanol)

INCI: DIMETHYL MEA

CAS Number
108-01-0
Function
Buffering agent, pH regulator
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 2.5%
🇺🇸 US Status permitted
US Notes No specific restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for DMAE (Dimethylaminoethanol). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 150 mg/kg bw/day oral rat oral REACH
NOAEL >7 mg/kg bw/day oral mouse oral REACH
NOAEL >240 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is severely irritating to the respiratory tract. The substance is corrosive to the eyes and skin. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Expert Verdict

DMAE is generally considered safe for use as a buffering agent and pH regulator in cosmetic formulations.

⚠️
Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is DMAE (Dimethylaminoethanol) safe in cosmetics?

DMAE is generally considered safe for use as a buffering agent and pH regulator in cosmetic formulations. The EU classifies DMAE (Dimethylaminoethanol) as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is DMAE (Dimethylaminoethanol) allowed in the EU?

DMAE (Dimethylaminoethanol) EU regulatory status: permitted. Maximum allowed concentration: 2.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does DMAE (Dimethylaminoethanol) do in cosmetics?

DMAE (Dimethylaminoethanol) functions as: Buffering agent, pH regulator. It is classified as a Active Ingredient in our database. CAS number: 108-01-0.

What is the Margin of Safety for DMAE (Dimethylaminoethanol)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for DMAE (Dimethylaminoethanol)?

The NOAEL (No Observed Adverse Effect Level) for DMAE (Dimethylaminoethanol) is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Compliance Tools

Check DMAE (Dimethylaminoethanol) compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

4-Butylresorcinol
Good
Tranexamic Acid
Excellent
Copper Peptide (GHK-Cu)
Good
Retinyl Propionate
Good
Glycine
Excellent
Browse all 30,000+ ingredients →
📱

Is DMAE (Dimethylaminoethanol) in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for DMAE (Dimethylaminoethanol) in your formulation.

Ingredient Decoder MoS Calculator