Epsilon-Caprolactone

INCI: EPSILON-CAPROLACTONE

CAS Number
502-44-3 [^1_10][^1_11]
Function
Solvent / monomer used as a precursor/additive in cosmetic formulations
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific prohibition under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Causes serious eye damage and skin irritation; may cause respiratory irritation. Must not be used near eyes at trace concentrations or above; in-use concentration in final cosmetic must be justified in CPSR with margin of safety calculation.

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Concern Level: Moderate

Frequently Asked Questions

Is Epsilon-Caprolactone safe in cosmetics?

Causes serious eye damage and skin irritation; may cause respiratory irritation. Must not be used near eyes at trace concentrations or above; in-use concentration in final cosmetic must be justified in CPSR with margin of safety calculation. The EU classifies Epsilon-Caprolactone as "permitted". Safety rating: MODERATE.

Is Epsilon-Caprolactone allowed in the EU?

Epsilon-Caprolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Epsilon-Caprolactone do in cosmetics?

Epsilon-Caprolactone functions as: Solvent / monomer used as a precursor/additive in cosmetic formulations. It is classified as a cosmetic ingredient in our database. CAS number: 502-44-3 [^1_10][^1_11].

What is the Margin of Safety for Epsilon-Caprolactone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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