Esculetin

INCI: ESCULETIN

CAS Number
305-01-1 [^1_5]
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific 21 CFR restriction; not CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Coumarin derivative with GHS classifications including skin irritation (Cat 2), eye irritation (Cat 2), and respiratory irritation (Cat 3); potential phototoxicity concern; anticoagulant-class compound with limited cosmetic-use concentration data.

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Concern Level: Moderate

Frequently Asked Questions

Is Esculetin safe in cosmetics?

Coumarin derivative with GHS classifications including skin irritation (Cat 2), eye irritation (Cat 2), and respiratory irritation (Cat 3); potential phototoxicity concern; anticoagulant-class compound with limited cosmetic-use concentration data. The EU classifies Esculetin as "permitted". Safety rating: MODERATE.

Is Esculetin allowed in the EU?

Esculetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Esculetin do in cosmetics?

Esculetin functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 305-01-1 [^1_5].

What is the Margin of Safety for Esculetin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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