Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Carnosine, relevant to systemic exposure and MoS calculations.
Source: Skin Pharmacol Physiol 2012
Expert Verdict
Carnosine is a multi-mechanism anti-pollution active with carbonyl scavenging, metal chelation, and anti-glycation properties. Endogenous dipeptide with extensive safety data; topical cosmetic concentrations (0.1-1%) are well within safety margins with no sensitization or irritation findings. Recommended for nighttime formulations at 0.2-0.5%.
Regulatory Flags
Frequently Asked Questions
Is Carnosine safe in cosmetics?
Carnosine is a multi-mechanism anti-pollution active with carbonyl scavenging, metal chelation, and anti-glycation properties. Endogenous dipeptide with extensive safety data; topical cosmetic concentrations (0.1-1%) are well within safety margins with no sensitization or irritation findings. Recommended for nighttime formulations at 0.2-0.5%. The EU classifies Carnosine as "permitted". Safety rating: EXCELLENT.
Is Carnosine allowed in the EU?
Carnosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carnosine do in cosmetics?
Carnosine functions as: Antioxidant; anti-pollution active; AhR pathway modulator; carbonyl scavenger; anti-glycation agent; dipeptide (beta-alanyl-L-histidine); metal chelator; anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 305-84-0.
What is the Margin of Safety for Carnosine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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