Moderate Cosmetic Ingredient NOAEL Data

Ethoxyethyl Methacrylate

INCI: ETHOXYETHYL METHACRYLATE

CAS Number
2370-63-0
Function
Film forming; artificial nail builder
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Allowed. CIR Expert Panel concluded it is safe as used in nail enhancement products when accompanied by directions to avoid skin contact.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Ethoxyethyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 20000 mg/L drinking water oral mouse oral REACH
NOAEL 1250 mg/L drinking water oral rat oral REACH
NOEL 23 mg/kg bw/day oral code:3544 oral REACH
NOAEL 163 mg/kg bw/day oral - oral REACH

Expert Verdict

Skin sensitization potential common to methacrylate monomers. The monomer is short-lived during normal nail application, so the primary hazard is inadvertent skin contact. Light-sensitive.. Molecular formula C₈H₁₄O₃, MW 158.19; also known as Ethylene Glycol Monoethyl Ether Methacrylate; forms a continuous film on nails.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Ethoxyethyl Methacrylate safe in cosmetics?

Skin sensitization potential common to methacrylate monomers. The monomer is short-lived during normal nail application, so the primary hazard is inadvertent skin contact. Light-sensitive.. Molecular formula C₈H₁₄O₃, MW 158.19; also known as Ethylene Glycol Monoethyl Ether Methacrylate; forms a continuous film on nails. The EU classifies Ethoxyethyl Methacrylate as "prohibited". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Ethoxyethyl Methacrylate allowed in the EU?

Ethoxyethyl Methacrylate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethoxyethyl Methacrylate do in cosmetics?

Ethoxyethyl Methacrylate functions as: Film forming; artificial nail builder. It is classified as a cosmetic ingredient in our database. CAS number: 2370-63-0.

What is the Margin of Safety for Ethoxyethyl Methacrylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethoxyethyl Methacrylate?

The NOAEL (No Observed Adverse Effect Level) for Ethoxyethyl Methacrylate is 20000 mg/L drinking water based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.

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