Poor Cosmetic Ingredient Sensitization Data

Ethyl Cyanoacrylate

INCI: ETHYL CYANOACRYLATE

CAS Number
7085-85-0 [^1_25]
Function
Film forming / adhesive (primarily nail glue, not a typical skincare ingredient)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” used in OTC nail adhesives; FDA-cleared for medical skin closure devices (2-octyl cyanoacrylate variant); no 21 CFR general cosmetic restriction but limited to adhesive applications

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Ethyl Cyanoacrylate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis

Source: IVDK

Expert Verdict

HIGH RISK: bonds skin/eyes in seconds; skin, eye, and respiratory irritant; exothermic polymerization can cause burns on large skin areas; very toxic to aquatic life (H410/H412); not suitable for leave-on skincare or mucous membrane contact; EUH202 mandatory labeling in EU

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Concern Level: High

Frequently Asked Questions

Is Ethyl Cyanoacrylate safe in cosmetics?

HIGH RISK: bonds skin/eyes in seconds; skin, eye, and respiratory irritant; exothermic polymerization can cause burns on large skin areas; very toxic to aquatic life (H410/H412); not suitable for leave-on skincare or mucous membrane contact; EUH202 mandatory labeling in EU The EU classifies Ethyl Cyanoacrylate as "permitted". Safety rating: POOR.

Is Ethyl Cyanoacrylate allowed in the EU?

Ethyl Cyanoacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Cyanoacrylate do in cosmetics?

Ethyl Cyanoacrylate functions as: Film forming / adhesive (primarily nail glue, not a typical skincare ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 7085-85-0 [^1_25].

What is the Margin of Safety for Ethyl Cyanoacrylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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