Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Ethyl Hexanoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 350 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 350 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | >=1000 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Fragrance ingredient with adequate margin of safety; IFRA use-level restrictions apply; not PBT; not phototoxic
Regulatory Flags
Frequently Asked Questions
Is Ethyl Hexanoate safe in cosmetics?
Fragrance ingredient with adequate margin of safety; IFRA use-level restrictions apply; not PBT; not phototoxic The EU classifies Ethyl Hexanoate as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Ethyl Hexanoate allowed in the EU?
Ethyl Hexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Hexanoate do in cosmetics?
Ethyl Hexanoate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 123-66-0.
What is the Margin of Safety for Ethyl Hexanoate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethyl Hexanoate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Hexanoate is 350 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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