Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Ethyl Isovalerate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 12.5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | >800 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >800 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >12.5 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Highly flammable; irritating to eyes, respiratory system, and skin at concentrated or undiluted levels; handle neat material with appropriate PPE.
Regulatory Flags
Frequently Asked Questions
Is Ethyl Isovalerate safe in cosmetics?
Highly flammable; irritating to eyes, respiratory system, and skin at concentrated or undiluted levels; handle neat material with appropriate PPE. The EU classifies Ethyl Isovalerate as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Ethyl Isovalerate allowed in the EU?
Ethyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Isovalerate do in cosmetics?
Ethyl Isovalerate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 108-64-5.
What is the Margin of Safety for Ethyl Isovalerate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethyl Isovalerate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Isovalerate is 12.5 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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