Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Ethyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2400 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 100 mg/kg bw/day | other | rat | other | REACH |
| NOAEL | 2400 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=124.1 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 310 ppm | 1991 | rat | inhalation | REACH |
| LOAEL | 179 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Acute toxicant (oral and dermal), skin and eye irritant, organ damage potential, flammable liquid. Occupational exposure risk for nail professionals; unsuitable for leave-on skin or lip products due to respiratory irritation risk.
Regulatory Flags
Frequently Asked Questions
Is Ethyl Methacrylate safe in cosmetics?
Acute toxicant (oral and dermal), skin and eye irritant, organ damage potential, flammable liquid. Occupational exposure risk for nail professionals; unsuitable for leave-on skin or lip products due to respiratory irritation risk. The EU classifies Ethyl Methacrylate as "restricted". Safety rating: POOR. 7 toxicological study endpoint(s) are available in our database.
Is Ethyl Methacrylate allowed in the EU?
Ethyl Methacrylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Methacrylate do in cosmetics?
Ethyl Methacrylate functions as: Film-forming agent for artificial nail systems. It is classified as a cosmetic ingredient in our database. CAS number: 97-63-2.
What is the Margin of Safety for Ethyl Methacrylate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethyl Methacrylate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Methacrylate is 2400 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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