Is Ethylene Dodecanedioate safe in cosmetics?
Ethylene Dodecanedioate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Ethylene Dodecanedioate
Also known as: 4-19-00-01935, BRN 0199405, Cyclic ethylene dodecanedioate, EINECS 259-423-6, Ethylene cyclic dodecanedioate (+3 more)
INCI: ETHYLENE DODECANEDIOATE
Ethylene Dodecanedioate (CAS 54982-83-1) is a cosmetic cosmetic ingredient functioning as Fragrance / masking agent. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 54982-83-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / masking agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
1,4-dioxacyclohexadecane-5,16-dione
InChIKey
GJJSUPSPZIZYPM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction; RIFM safety-assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylene Dodecanedioate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethylene Dodecanedioate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
12400 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [452] Kligman AM (1978): Report to RIFM, 28 February, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
| HRIPT | - | 0 | 12400.02 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethylene Dodecanedioate.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
Known Synonyms
4-19-00-01935
BRN 0199405
Cyclic ethylene dodecanedioate
EINECS 259-423-6
Ethylene cyclic dodecanedioate
Ethylenedodecanedioate
Muskonate
UNII-NBW53A4P49
Chemical Function
Fragrance
Deodorizer
Regulatory Lists
IFRA Transparency
consumer_product
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186723
Frequently Asked Questions
Is Ethylene Dodecanedioate allowed in the EU?
Ethylene Dodecanedioate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylene Dodecanedioate do in cosmetics?
Ethylene Dodecanedioate functions as: Fragrance / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 54982-83-1.
Is Ethylene Dodecanedioate used outside cosmetics?
Ethylene Dodecanedioate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethylene Dodecanedioate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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