Moderate Cosmetic Ingredient Sensitization Data

Eucalyptus Globulus (Eucalyptus) Oil

INCI: EUCALYPTUS GLOBULUS OIL

CAS Number
97926-40-4 / 8000-48-4
Function
Perfuming, skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Allowed in cosmetics without restriction. Also permitted as a food additive (21 CFR 172.510) and in certain OTC drug products.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Eucalyptus Globulus (Eucalyptus) Oil based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
terpene-hydroperoxide-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: IFRA

Expert Verdict

Contains eucalyptol (1,8-cineole) at 54-95%. Potential dermal sensitizer at high concentrations; can cause CNS and breathing problems in young children. Penetration enhancement properties mean it can increase absorption of other actives.. This is the broad "eucalyptus oil" designation (covering extractives from the genus). Distinct from the more specific "Leaf Oil" INCI, which specifies leaf-only sourcing.

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Concern Level: Moderate

Regulatory Flags

plant-oil potential-allergen fragrance-component

Frequently Asked Questions

Is Eucalyptus Globulus (Eucalyptus) Oil safe in cosmetics?

Contains eucalyptol (1,8-cineole) at 54-95%. Potential dermal sensitizer at high concentrations; can cause CNS and breathing problems in young children. Penetration enhancement properties mean it can increase absorption of other actives.. This is the broad "eucalyptus oil" designation (covering extractives from the genus). Distinct from the more specific "Leaf Oil" INCI, which specifies leaf-only sourcing. The EU classifies Eucalyptus Globulus (Eucalyptus) Oil as "restricted". Safety rating: MODERATE.

Is Eucalyptus Globulus (Eucalyptus) Oil allowed in the EU?

Eucalyptus Globulus (Eucalyptus) Oil EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Eucalyptus Globulus (Eucalyptus) Oil do in cosmetics?

Eucalyptus Globulus (Eucalyptus) Oil functions as: Perfuming, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 97926-40-4 / 8000-48-4.

What is the Margin of Safety for Eucalyptus Globulus (Eucalyptus) Oil?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Eucalyptus Globulus (Eucalyptus) Oil compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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