Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for gamma-Decalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 400 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | mouse | Neurotoxicity | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | mouse | Neurotoxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant safety concerns. Not genotoxic (read-across from gamma-octalactone and gamma-nonalactone); not phototoxic or photoallergenic per UV spectra.
Regulatory Flags
Frequently Asked Questions
Is gamma-Decalactone safe in cosmetics?
No significant safety concerns. Not genotoxic (read-across from gamma-octalactone and gamma-nonalactone); not phototoxic or photoallergenic per UV spectra. The EU classifies gamma-Decalactone as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.
Is gamma-Decalactone allowed in the EU?
gamma-Decalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Decalactone do in cosmetics?
gamma-Decalactone functions as: Fragrance / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 706-14-9.
What is the Margin of Safety for gamma-Decalactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for gamma-Decalactone?
The NOAEL (No Observed Adverse Effect Level) for gamma-Decalactone is 400 mg/kg bw/day based on a Special Toxicology Study study via oral route in mouse. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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