Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for gamma-Dodecalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.750 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Fragrance ingredient with excellent safety profile; causes mild skin irritation only at high concentrations. Not genotoxic, not PBT, and environmentally safe (PEC/PNEC < 1).
Regulatory Flags
Frequently Asked Questions
Is gamma-Dodecalactone safe in cosmetics?
Fragrance ingredient with excellent safety profile; causes mild skin irritation only at high concentrations. Not genotoxic, not PBT, and environmentally safe (PEC/PNEC < 1). The EU classifies gamma-Dodecalactone as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is gamma-Dodecalactone allowed in the EU?
gamma-Dodecalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Dodecalactone do in cosmetics?
gamma-Dodecalactone functions as: Fragrance, masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 2305-05-7.
What is the Margin of Safety for gamma-Dodecalactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for gamma-Dodecalactone?
The NOAEL (No Observed Adverse Effect Level) for gamma-Dodecalactone is ca.750 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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