Is Geranial safe in cosmetics?
Geranial has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Geranial
INCI: GERANIAL
Geranial (CAS 141-27-5) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 141-27-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Geranial is classified GHS CMR hazard (H315, H317, H319, H227, H361) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance (perfuming)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2E)-3,7-dimethylocta-2,6-dienal
InChIKey
WTEVQBCEXWBHNA-JXMROGBWSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — FDA GRAS as flavoring (21 CFR 182.60); no specific cosmetic restriction; geraniol/citral assessed by RIFM
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Geranial.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Citral | TR-505: Toxicology and Carcinogenesis Studies of Citral (Microencapsulated) (CASRN 5392-40-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) (2003 ) | 05/03/01 | No Evidence | No Evidence | No Evidence | Equivocal Evidence | Under the conditions of these 2-year feed studies, there was no evidence of carcinogenic activity of citral in male or female F344/N rats exposed to 1,000, 2,
Source: NTP Technical Reports
ICSC Safety Card
1725
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritant effect of 19 oils & 20 synthetic perfumes used in cosmetics were tested on skin of 50 male volunteers. Citral @ 32% concn was the most irritating of perfumes in human patch test. | Irritating to skin. | A cumulative irritation study was carried out on 8 volunteers. Patches were placed on the back daily, removed at 24 hr and read and them replaced with a fresh patch, over a period of 21 da
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
1225
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,7-DIMETHYL-2,6-OCTADIENAL | 2003 | 0-0.5 mg/kg bw (1979) | Use of citral as a flavouring agent is subsumed in the 1979 group ADI of 0-0.5 mg/kg bw for citral, geranyl acetate, citronellol, linalool, and linallyl acetate, expressed as citral, which was mainted at the sixty-first meeting. | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Geranial.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CITRAL
ChEMBL ID
CHEMBL1080997
Frequently Asked Questions
Is Geranial allowed in the EU?
Geranial EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Geranial do in cosmetics?
Geranial functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 141-27-5.
Is Geranial used outside cosmetics?
Geranial also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Geranial have different safety status in cosmetics vs industrial chemicals?
Geranial is classified GHS CMR hazard (H315, H317, H319, H227, H361) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Geranial compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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